Hongyuan Ding 1, Yi Zhu 2, Han Wu 3, Ling Zhang 1, Yaxin Gao 4, Qian Zhong 4, Qiumin Zhou 2, Ming Qi 1, Long Qian 5, Weiqiang Dou5, and Tong Wang2
1Radiology department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 2Rehabilitation Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 3Rehabilitation Department, Nanjing Drum Tower Hospital, The Affiliated Hospital of the Medical School at Nanjing University, Nanjing, China, 4Nanjing Medical University, Nanjing, China, 5MR Research China, GE Healthcare, Beijing, China
In
this study, the whole brain cerebral
blood perfusion (CBF) values have been respectively investigated for patients
with subjective cognitive
decline (SCD) and mild cognitive impairment (MCI) and healthy controls
(HCs). Significantly lower CBF
values for the left superior frontal gyrus, left middle frontal gyrus, and left
caudate nucleus regions have been shown in SCD patients than HCs. Additionally,
the CBFs at these regions also showed strong correlations with multiple
clinical scales. Therefore, CBF can be considered an effective tool in the
early detection of SCD patients.
