Abstract #1492

Aberrant cerebral blood flow in patients with subjective cognitive decline: a whole-brain atlas based analysis

Hongyuan Ding ¹, Yi Zhu ², Han Wu ³, Ling Zhang ¹, Yaxin Gao ⁴, Qian Zhong ⁴, Qiumin Zhou ², Ming Qi ¹, Long Qian ⁵, Weiqiang Dou⁵, and Tong Wang²

¹Radiology department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ²Rehabilitation Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ³Rehabilitation Department, Nanjing Drum Tower Hospital, The Affiliated Hospital of the Medical School at Nanjing University, Nanjing, China, ⁴Nanjing Medical University, Nanjing, China, ⁵MR Research China, GE Healthcare, Beijing, China

In this study, the whole brain cerebral blood perfusion (CBF) values have been respectively investigated for patients with subjective cognitive decline (SCD) and mild cognitive impairment (MCI) and healthy controls (HCs). Significantly lower CBF values for the left superior frontal gyrus, left middle frontal gyrus, and left caudate nucleus regions have been shown in SCD patients than HCs. Additionally, the CBFs at these regions also showed strong correlations with multiple clinical scales. Therefore, CBF can be considered an effective tool in the early detection of SCD patients.

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