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Abstract #1494

Quantitative susceptibility mapping of brain iron deposition in patients with cerebral small-vessel disease with cerebral microbleeds

Lingfei Guo1,2, Liangdong Zhou1, Thanh D. Nguyen1, Weiyuan Huang1, Junghun Cho1, and Yi Wang1
1Weill Cornell Medicine, Cornell University, New York, NY, United States, 2Shandong Medical Imaging Research Institute Affiliated to Shandong University, Jinan, China

Quantitative susceptibility mapping (QSM) was used to evaluate and compare the characteristics of iron deposition in gray matter nuclei of the brain between patients with cerebral small-vessel disease and cerebral microbleeds (CSVD-CMBs) and those with CSVD and no CMBs(CSVD–no CMBs). The susceptibility values of the bilateral caudate nucleus, putamen, red nucleus, and substantia nigra were significantly higher in patients with CSVD-CMBs than in those with CSVD–no CMBs and in healthy controls. The change in the susceptibility values of these regions may be an imaging marker of cognitive decline in patients with CSVD.

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