Quantitative susceptibility mapping (QSM) was used to evaluate and compare the characteristics of iron deposition in gray matter nuclei of the brain between patients with cerebral small-vessel disease and cerebral microbleeds (CSVD-CMBs) and those with CSVD and no CMBs（CSVD–no CMBs). The susceptibility values of the bilateral caudate nucleus, putamen, red nucleus, and substantia nigra were significantly higher in patients with CSVD-CMBs than in those with CSVD–no CMBs and in healthy controls. The change in the susceptibility values of these regions may be an imaging marker of cognitive decline in patients with CSVD.
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