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Abstract #1495

Magnetic Resonance Fingerprinting May Differentiate Parkinson’s Disease From Healthy Controls

Yan Bai1, Rushi Chen1, Rui Zhang1, Wei Wei1, Ying Wang1, Mathias Nittka2, Gregor Koerzdoerfer2, Xianchang Zhang3, and Meiyun Wang1
1Department of Medical Imaging, Henan Provincial People's Hospital, Zhengzhou, China, 2MR Pre-development, Siemens Healthcare, Erlangen, Germany, 3MR Collaboration, Siemens Healthcare Ltd, Beijing, China

Magnetic resonance parametric mapping techniques such as T1 and T2 relaxation time mapping have been used to capture the potential Parkinson’s disease (PD)-related changes in the substantia nigra (SN). However, the findings in different studies were inconsistent. This study utilized a novel technique magnetic resonance fingerprinting (MRF) to obtain T1 and T2 values on thirty patients with PD and thirty matched healthy controls. Comparison results found that T1 values of the left and right SN in the PD patients were significantly higher than in healthy controls. T1 values in the SN acquired by MRF may differentiate PD from healthy controls.

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