Abstract #1495

Magnetic Resonance Fingerprinting May Differentiate Parkinson’s Disease From Healthy Controls

Yan Bai¹, Rushi Chen¹, Rui Zhang¹, Wei Wei¹, Ying Wang¹, Mathias Nittka², Gregor Koerzdoerfer², Xianchang Zhang³, and Meiyun Wang¹

¹Department of Medical Imaging, Henan Provincial People's Hospital, Zhengzhou, China, ²MR Pre-development, Siemens Healthcare, Erlangen, Germany, ³MR Collaboration, Siemens Healthcare Ltd, Beijing, China

Magnetic resonance parametric mapping techniques such as T1 and T2 relaxation time mapping have been used to capture the potential Parkinson’s disease (PD)-related changes in the substantia nigra (SN). However, the findings in different studies were inconsistent. This study utilized a novel technique magnetic resonance fingerprinting (MRF) to obtain T1 and T2 values on thirty patients with PD and thirty matched healthy controls. Comparison results found that T1 values of the left and right SN in the PD patients were significantly higher than in healthy controls. T1 values in the SN acquired by MRF may differentiate PD from healthy controls.

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