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Abstract #1496

Different patterns of perfusion changes in tremor-dominant Parkinson’s disease and essential tremor using 3D arterial spin labeling imaging

Yong Zhang1, Jian Wang2, Chang-Peng Wang2, Li-Rong Jin2, and Bing Wu3
1GE Healthcare, Shanghai, China, 2Zhongshan Hospital, Shanghai, China, 3GE Healthcare, Beijing, China

This preliminary study aimed to identify potential markers in diagnosis of tremor disorders such as tremor-dominant Parkinson’s disease (PDT) and essential tremor (ET). A novel 3D pulsed-continuous arterial spin labeling technique (3D pCASL) was used to provide whole brain quantitative perfusion measurement, followed by voxel-wise comparison to evaluate regional CBF characteristics in patients with PDT, ET and age- and gender- matched healthy controls. PDT patients showed decreased CBF in the caudate and precuneus when compared to ET patients. The altered metabolic patterns of PDT and ET can help to understand different pathophysiological mechanism of tremor disorders.

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