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Abstract #1497

Fixel-based analysis on white matter changes in patients with Parkinson's disease, progressive supranuclear palsy and multiple system atrophy

Nguyen Thanh Thao1, Chih-Chien Tsai2, Yao-Liang Chen3, Jur-Shan Cheng4, Chin-Song Lu5, Yi-Hsin Weng5, Sung-han Lin4, Po-Yuan Chen4, and Jiun-Jie Wang6
1Department of Radiology, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam, 2Healthy Aging Research Center, Chang-Gung University, TaoYuan, Taiwan, 3Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Keelung Branch, Keelung, Taiwan, 4Chang-Gung University, TaoYuan, Taiwan, 5Division of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital, Linkou Branch, TaoYuan, Taiwan, 6Department of Medical Imaging and Radiological Sciences, Chang-Gung University, TaoYuan, Taiwan

White matter degeneration have been attributed to the motor and non-motor symptoms of Parkinson’s disease and atypical parkinsonism. Our study shows different pattern of white matter changes in multiple system atrophy and progressive supranuclear palsy compared to Parkinson’s disease. Furthermore, different affected areas of white matter changes were found among atypical parkinsonism. The involved regions are consistent with the understanding of the pathogenesis of the diseases. Our result proves that fixel based analysis is a robust technique to study white matter degeneration in PD and atypical parkinsonism.

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