Abstract #1497

Fixel-based analysis on white matter changes in patients with Parkinson's disease, progressive supranuclear palsy and multiple system atrophy

Nguyen Thanh Thao¹, Chih-Chien Tsai², Yao-Liang Chen³, Jur-Shan Cheng⁴, Chin-Song Lu⁵, Yi-Hsin Weng⁵, Sung-han Lin⁴, Po-Yuan Chen⁴, and Jiun-Jie Wang⁶

¹Department of Radiology, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam, ²Healthy Aging Research Center, Chang-Gung University, TaoYuan, Taiwan, ³Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Keelung Branch, Keelung, Taiwan, ⁴Chang-Gung University, TaoYuan, Taiwan, ⁵Division of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital, Linkou Branch, TaoYuan, Taiwan, ⁶Department of Medical Imaging and Radiological Sciences, Chang-Gung University, TaoYuan, Taiwan

White matter degeneration have been attributed to the motor and non-motor symptoms of Parkinson’s disease and atypical parkinsonism. Our study shows different pattern of white matter changes in multiple system atrophy and progressive supranuclear palsy compared to Parkinson’s disease. Furthermore, different affected areas of white matter changes were found among atypical parkinsonism. The involved regions are consistent with the understanding of the pathogenesis of the diseases. Our result proves that fixel based analysis is a robust technique to study white matter degeneration in PD and atypical parkinsonism.

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