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Abstract #1498

Perfusion-Based Biomarkers of Mild Cognitive Impairment in Parkinson’s disease with different MAPT haplotypes using Arterial Spin Labeling MRI

Dilek Betul Arslan1, Hakan Ibrahim Gurvit2, Ozan Genc1, Ani Kicik3,4, Kardelen Eryurek3,5, Sevim Cengiz1, Emel Erdogdu3,6, Zerrin Yildirim2, Zeynep Tufekcioglu2, Aziz Mufit Ulug1,7, Basar Bilgic2, Hasmet Hanagasi2, Erdem Tuzun5, Tamer Demiralp3,8, and Esin Ozturk-Isik1
1Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey, 2Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, 3Neuroimaging Unit, Hulusi Behcet Life Sciences Research Center, Istanbul University, Istanbul, Turkey, 4Department of Physiology, Faculty of Medicine, Demiroglu Bilim University, Istanbul, Turkey, 5Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey, 6Department of Psychology, Faculty of Arts and Sciences, Isik University, Istanbul, Turkey, 7CorTechs Labs, San Diego, CA, United States, 8Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

The main purpose of this study was to define possible brain perfusion deficits in risky gene carriers in Parkinson’s disease (PD) using arterial spin labeling magnetic resonance imaging (ASL-MRI). Cerebral blood flow (CBF) maps of PD and mild cognitively impaired PD (PD-MCI) with different microtubule-associated protein tau (MAPT) genotypes were compared using a voxelwise analysis. The CBF values were evaluated at brain parcellations obtained from resting-state functional MRI. Hypoperfusion in several brain regions, corresponding to the visual network, default mode network, and frontoparietal network, was observed in PD patients with MAPT H1/H1 haplotype.

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