Abstract #1498

Perfusion-Based Biomarkers of Mild Cognitive Impairment in Parkinson’s disease with different MAPT haplotypes using Arterial Spin Labeling MRI

Dilek Betul Arslan¹, Hakan Ibrahim Gurvit², Ozan Genc¹, Ani Kicik^3,4, Kardelen Eryurek^3,5, Sevim Cengiz¹, Emel Erdogdu^3,6, Zerrin Yildirim², Zeynep Tufekcioglu², Aziz Mufit Ulug^1,7, Basar Bilgic², Hasmet Hanagasi², Erdem Tuzun⁵, Tamer Demiralp^3,8, and Esin Ozturk-Isik¹

¹Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey, ²Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, ³Neuroimaging Unit, Hulusi Behcet Life Sciences Research Center, Istanbul University, Istanbul, Turkey, ⁴Department of Physiology, Faculty of Medicine, Demiroglu Bilim University, Istanbul, Turkey, ⁵Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey, ⁶Department of Psychology, Faculty of Arts and Sciences, Isik University, Istanbul, Turkey, ⁷CorTechs Labs, San Diego, CA, United States, ⁸Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

The main purpose of this study was to define possible brain perfusion deficits in risky gene carriers in Parkinson’s disease (PD) using arterial spin labeling magnetic resonance imaging (ASL-MRI). Cerebral blood flow (CBF) maps of PD and mild cognitively impaired PD (PD-MCI) with different microtubule-associated protein tau (MAPT) genotypes were compared using a voxelwise analysis. The CBF values were evaluated at brain parcellations obtained from resting-state functional MRI. Hypoperfusion in several brain regions, corresponding to the visual network, default mode network, and frontoparietal network, was observed in PD patients with MAPT H1/H1 haplotype.

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