Abstract #1499

The Cerebral Blood Flow Changes in Parkinson’s Disease with Mild Cognitive Impairment Using Arterial Spin Labeling MRI

Dilek Betul Arslan¹, Hakan Ibrahim Gurvit², Ozan Genc¹, Ani Kicik^3,4, Kardelen Eryurek^3,5, Sevim Cengiz¹, Emel Erdogdu^3,6, Zerrin Yildirim², Zeynep Tufekcioglu², Aziz Mufit Ulug^1,7, Basar Bilgic², Hasmet Hanagasi², Tamer Demiralp^3,8, and Esin Ozturk-Isik¹

¹Biomedical Engineering Institution, Bogazici University, Istanbul, Turkey, ²Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, ³Neuroimaging Unit, Hulusi Behcet Life Sciences Research Center, Istanbul University, Istanbul, Turkey, ⁴Department of Physiology, Faculty of Medicine, Demiroglu Bilim University, Istanbul, Turkey, ⁵Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey, ⁶Department of Psychology, Faculty of Arts and Sciences, Isik University, Istanbul, Turkey, ⁷CorTechs Labs, San Diego, CA, United States, ⁸Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

The main aim of this study is to define possible brain perfusion-based signatures based on voxelwise comparison of cerebral blood flow (CBF) maps of Parkinson’s disease (PD) with mild cognitive impairment, cognitively normal PD and healthy controls. CBF maps were calculated by fitting a general kinetic curve model with Look-Locker readout for each pixel of arterial spin labeling MR (ASL-MR) images. The pattern of posterior hypoperfusion has been observed in PD in line with cognitive impairment.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.