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Abstract #1499

The Cerebral Blood Flow Changes in Parkinson’s Disease with Mild Cognitive Impairment Using Arterial Spin Labeling MRI

Dilek Betul Arslan1, Hakan Ibrahim Gurvit2, Ozan Genc1, Ani Kicik3,4, Kardelen Eryurek3,5, Sevim Cengiz1, Emel Erdogdu3,6, Zerrin Yildirim2, Zeynep Tufekcioglu2, Aziz Mufit Ulug1,7, Basar Bilgic2, Hasmet Hanagasi2, Tamer Demiralp3,8, and Esin Ozturk-Isik1
1Biomedical Engineering Institution, Bogazici University, Istanbul, Turkey, 2Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, 3Neuroimaging Unit, Hulusi Behcet Life Sciences Research Center, Istanbul University, Istanbul, Turkey, 4Department of Physiology, Faculty of Medicine, Demiroglu Bilim University, Istanbul, Turkey, 5Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey, 6Department of Psychology, Faculty of Arts and Sciences, Isik University, Istanbul, Turkey, 7CorTechs Labs, San Diego, CA, United States, 8Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

The main aim of this study is to define possible brain perfusion-based signatures based on voxelwise comparison of cerebral blood flow (CBF) maps of Parkinson’s disease (PD) with mild cognitive impairment, cognitively normal PD and healthy controls. CBF maps were calculated by fitting a general kinetic curve model with Look-Locker readout for each pixel of arterial spin labeling MR (ASL-MR) images. The pattern of posterior hypoperfusion has been observed in PD in line with cognitive impairment.

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