Abstract #1500

Quantitative assessment of abnormal susceptibility, R1 and R2* changes in the deep gray matter nuclei in Parkinson’s disease and essential tremor

Kiarash Ghassaban^1,2, Sean Kumar Sethi^1,2, David Utriainen³, Zenghui Cheng⁴, Pei Huang⁵, Yan Li⁴, Rongbio Tang ⁴, Paul Kokeny³, Kiran Kumar Yerramsetty⁶, Vinay Kumar Palutla⁶, Shengdi Chen ⁵, Fuhua Yan⁴, and Ewart Mark Haacke^1,2,4

¹Radiology, Wayne State University, Detroit, MI, United States, ²Biomedical Engineering, Wayne State University, Detroit, MI, United States, ³SpinTech, Bingham Farms, MI, United States, ⁴Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁵Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁶MR Medical Imaging Innovations, Telangana, India

This work proposes two investigated problems. The first is the separation of confounding tissue properties of deep gray matter using R1, R2*, and QSM from a 3D GRE protocol known as STAGE by sampling a distribution of low and high iron regions across subjects, including very high iron regions in aceruloplasminemia. The second is investigating if we see any differences in these structures in Parkinson’s Disease, essential tremor, and healthy control subjects. These problems are investigated to show that susceptibility changes and R1 are linked, and that water and iron related changes are observable when comparing controls versus Parkinson’s Disease

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