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Abstract #1500

Quantitative assessment of abnormal susceptibility, R1 and R2* changes in the deep gray matter nuclei in Parkinson’s disease and essential tremor

Kiarash Ghassaban1,2, Sean Kumar Sethi1,2, David Utriainen3, Zenghui Cheng4, Pei Huang5, Yan Li4, Rongbio Tang 4, Paul Kokeny3, Kiran Kumar Yerramsetty6, Vinay Kumar Palutla6, Shengdi Chen 5, Fuhua Yan4, and Ewart Mark Haacke1,2,4
1Radiology, Wayne State University, Detroit, MI, United States, 2Biomedical Engineering, Wayne State University, Detroit, MI, United States, 3SpinTech, Bingham Farms, MI, United States, 4Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 5Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 6MR Medical Imaging Innovations, Telangana, India

This work proposes two investigated problems. The first is the separation of confounding tissue properties of deep gray matter using R1, R2*, and QSM from a 3D GRE protocol known as STAGE by sampling a distribution of low and high iron regions across subjects, including very high iron regions in aceruloplasminemia. The second is investigating if we see any differences in these structures in Parkinson’s Disease, essential tremor, and healthy control subjects. These problems are investigated to show that susceptibility changes and R1 are linked, and that water and iron related changes are observable when comparing controls versus Parkinson’s Disease

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