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Abstract #1501

Exploration of structural brain volume changes in patients with early- and middle-late-onset Parkinson's disease using the MPRAGE sequence

Ruichen Zhao1, Chunyan Zhang1, Jinxia Zhu2, Bénédicte Maréchal3, Chen Chen1, Hong Lu4, and Jingliang Cheng1
1Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2MR Collaboration, Siemens Healthcare Ltd., Beijing, China, 3Advanced Clinical Imaging Technology, Siemens Healthcare AG;Department of Radiology, Lausanne University Hospital and University of Lausanne;LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 4Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

In this study, the structural brain volume changes in early-onset (EOPD) and middle-late-onset Parkinson’s disease (M-LOPD) patients were evaluated. We found different patterns of volume changes in these patients. The results showed that some brain regions might represent a potential imaging marker for the early diagnosis of EOPD and could explain different clinical characteristics. MPRAGE-based morphometry may be a suitable method to provide a reference for EOPD diagnoses in clinical practice.

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