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Abstract #1502

Localization of the iron deposits along myelinated fibers within the substantia nigra of progressive supranuclear palsy on brain MRI

Hansol Lee1, Sun-Yong Baek2, Eun-Joo Kim3, Gi Yeong Huh4, Jae-Hyeok Lee5, and HyungJoon Cho1
1Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of, 2Department of Anatomy, Pusan National University School of Medicine, Yangsan, Korea, Republic of, 3Department of Neurology, Pusan National University Hospital, Busan, Korea, Republic of, 4Department of Forensic Medicine, Pusan National University School of Medicine, Yangsan, Korea, Republic of, 5Department of Neurology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea, Republic of

The purpose of this study was to determine the morphology change in the substantia nigra of progressive supranuclear palsy using MRI with histopathological validation. MR experiments for progressive supranuclear palsy brains were operated using 3T in vivo and 7T postmortem imaging systems. Perls’ Prussian blue staining, Luxol fast blue staining, and LA-ICP-MS for 2D iron mapping confirmed the large amount of iron deposits along the myelinated fibers within substantia nigra of PSP brain. The iron deposits along the myelinated fibers could be the potential source causing the blurred boundary between red nucleus and substantia nigra in in vivo MRI.

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