Parkinson’s disease (PD) is the second most common neurodegenerative disease and its related brain changes appear not to be localized in isolate region but rather in the networks. We desire to exploring the large-scale structural and functional networks change which are of great importance for understanding the mechanism of disease. Moreover, it deserves to further answer the unsolved question that whether a functional compensation resulting from structural network disruption and whether such effect would be lasting or changed longitudinally.
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