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Abstract #1505

Differential clinical associations of Periventricular and Deep White Matter Hyperintensities on FLAIR

Han Yu1, Jingyun Chen1, Henry Rusinek2, and Yulin Ge3
1Department of Neurology, New York University School of Medicine, New York, NY, United States, 2Department of Neurology and Radiology, New York University School of Medicine, New York, NY, United States, 3Department of Radiology, New York University School of Medicine, New York, NY, United States

In this study, we examined the differences of two subtypes of white matter hyperintensities (WMHs), periventricular WMHs (PVWMH) and deep WMHs (DWMH) on MRI, as they associate with cognitive dysfunction and dementia, and other clinical assessments of the elderly. A robust computational method (Bilateral Distance classification) was implemented to quantify PVWMH and DWMH. Clinical associations revealed by the algorithm are consistent with the literature findings based on subjective classification methods that the two types of WMHs have differential clinical associations and may have different pathological etiologies and roles in cognitive impairment and dementia.

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