In this study, we examined the differences of two subtypes of white matter hyperintensities (WMHs), periventricular WMHs (PVWMH) and deep WMHs (DWMH) on MRI, as they associate with cognitive dysfunction and dementia, and other clinical assessments of the elderly. A robust computational method (Bilateral Distance classification) was implemented to quantify PVWMH and DWMH. Clinical associations revealed by the algorithm are consistent with the literature findings based on subjective classification methods that the two types of WMHs have differential clinical associations and may have different pathological etiologies and roles in cognitive impairment and dementia.
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