Abstract #1506

Investigation of iron-sensitive MRI biomarkers for non-motor symptoms in early stage Parkinson’s disease

Seulki Yoo^1,2, MinKyeong Kim^3,4, Doyeon Kim⁵, Jin Whan Cho^3,4, Ji Sun Kim^3,4, Jong Hyun Ahan^3,4, Jun Kyu Mun^3,4, Jinyoung Youn^3,4, and Seung-Kyun Lee^1,2

¹Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, ²Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of, ³Department of Neurology, Samsung Medical Center, Seoul, Korea, Republic of, ⁴Neuroscience Center, Samsung Medical Center, Seoul, Korea, Republic of, ⁵Department of Biomedical Engineering, Gachon University, Incheon, Korea, Republic of

Deep brain iron accumulation in Parkinson’s disease (PD) has been much studied in MRI but its involvement in clinical non-motor symptoms has been inconclusive. In this work we investigated the correlation between the deep brain iron contents and a wide array of non-motor symptoms in drug naive early PD patients using QSM and R2* mapping at 3T. We found that many non-motor symptoms are significantly correlated with R2* in the extra-striatal system, in particular the thalamus and red nucleus.

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