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Abstract #1506

Investigation of iron-sensitive MRI biomarkers for non-motor symptoms in early stage Parkinson’s disease 

Seulki Yoo1,2, MinKyeong Kim3,4, Doyeon Kim5, Jin Whan Cho3,4, Ji Sun Kim3,4, Jong Hyun Ahan3,4, Jun Kyu Mun3,4, Jinyoung Youn3,4, and Seung-Kyun Lee1,2
1Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, 2Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of, 3Department of Neurology, Samsung Medical Center, Seoul, Korea, Republic of, 4Neuroscience Center, Samsung Medical Center, Seoul, Korea, Republic of, 5Department of Biomedical Engineering, Gachon University, Incheon, Korea, Republic of

Deep brain iron accumulation in Parkinson’s disease (PD) has been much studied in MRI but its involvement in clinical non-motor symptoms has been inconclusive. In this work we investigated the correlation between the deep brain iron contents and a wide array of non-motor symptoms in drug naive early PD patients using QSM and R2* mapping at 3T. We found that many non-motor symptoms are significantly correlated with R2* in the extra-striatal system, in particular the thalamus and red nucleus.

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