Cholesterol-transporter ApoE4 is involved in lipid metabolism and is associated with neurodegenerative diseases. Studies show, functional connectivity(FC) in ApoE4 mice is significantly deviating from ApoE3 and Wild-Type(WT). Underlining cause of these differences are less explored. Since myelin is mostly comprised of cholesterol, we investigated if a change in white matter integrity(WMI) could have contributed to the FC changes. FC and WMI in ApoE4 are distinctively different from ApoE3 and WT as shown by our results. Our results within the auditory cortex show that an increase in FA in ApoE4 is associated with a decrease of FC in the region.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords