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Abstract #1509

Comparison of T1/T2 values of white matter and deep gray matter between healthy controls and Parkinson’s disease patients using plug-and-play MRF

Koji Fujimoto1, Martijn A. Cloos2, Atsushi Shima3, Thuy Dinh Ha Duy1, Nobukatsu Sawamoto4, Ryosuke Takahashi3, Tadashi Isa1,5, and Tomohisa Okada1
1Human Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Center for Advanced Imaging Innovation and Research (CAI2R) and Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, 3Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan, 4Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan, 5Department of Neuroscience, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan

To investigate changes in T1 and T2 of deep gray matter in Parkinson’s disease (PD) patients at 7T, healthy volunteers (N=104, age range 20-77) and PD patients (N=42, age range 50-72) were scanned using a 1ch-Tx/32ch-Rx coil and a Plug-and-Play MR Fingeprinting (prototype) sequence. ROIs were drawn in six regions (left and right putamen, globus pallidus, caudate head, thalamus, frontal white matter (WM)) and a linear and quadratic curve fitting was performed. T2 value of the putamen was larger in PD than the age-matched subgroup of HC, but was not significant.

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