Abstract #1509

Comparison of T1/T2 values of white matter and deep gray matter between healthy controls and Parkinson’s disease patients using plug-and-play MRF

Koji Fujimoto¹, Martijn A. Cloos², Atsushi Shima³, Thuy Dinh Ha Duy¹, Nobukatsu Sawamoto⁴, Ryosuke Takahashi³, Tadashi Isa^1,5, and Tomohisa Okada¹

¹Human Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Center for Advanced Imaging Innovation and Research (CAI2R) and Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, ³Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁴Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁵Department of Neuroscience, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan

To investigate changes in T1 and T2 of deep gray matter in Parkinson’s disease (PD) patients at 7T, healthy volunteers (N=104, age range 20-77) and PD patients (N=42, age range 50-72) were scanned using a 1ch-Tx/32ch-Rx coil and a Plug-and-Play MR Fingeprinting (prototype) sequence. ROIs were drawn in six regions (left and right putamen, globus pallidus, caudate head, thalamus, frontal white matter (WM)) and a linear and quadratic curve fitting was performed. T2 value of the putamen was larger in PD than the age-matched subgroup of HC, but was not significant.

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