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Abstract #1512

ViSTa Myelin Water Imaging in Parkinson’s Disease

Septian Hartono1,2, Leon Qi Rong Ooi3, Amanda May Yeng Choo1, Celeste Yan Teng Chen1, Amanda Jieying Lee4, Weiling Lee4, Pik Hsien Chai4, Kuan Jin Lee5, Jongho Lee6, Eng King Tan1,2, and Ling Ling Chan2,4
1National Neuroscience Institute, Singapore, Singapore, 2Duke-NUS Medical School, Singapore, Singapore, 3National University of Singapore, Singapore, Singapore, 4Singapore General Hospital, Singapore, Singapore, 5Singapore BioImaging Consortium, Singapore, Singapore, 6Seoul National University, Seoul, Republic of Korea

There is increasing evidence that myelin can be directly involved in Parkinson's disease (PD). We investigated the utility of ViSTa myelin water imaging (MWI) to characterize changes in myelination in PD. Slight decrease of global white matter myelin water fraction (MWF) was observed in PD patients. MWF was also associated with cognitive status, while no such association was found between DTI metrics and cognitive status. These indicated that MWF may potentially be a more specific biomarker for dysmyelination in the brain.

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