Abstract #1512

ViSTa Myelin Water Imaging in Parkinson’s Disease

Septian Hartono^1,2, Leon Qi Rong Ooi³, Amanda May Yeng Choo¹, Celeste Yan Teng Chen¹, Amanda Jieying Lee⁴, Weiling Lee⁴, Pik Hsien Chai⁴, Kuan Jin Lee⁵, Jongho Lee⁶, Eng King Tan^1,2, and Ling Ling Chan^2,4

¹National Neuroscience Institute, Singapore, Singapore, ²Duke-NUS Medical School, Singapore, Singapore, ³National University of Singapore, Singapore, Singapore, ⁴Singapore General Hospital, Singapore, Singapore, ⁵Singapore BioImaging Consortium, Singapore, Singapore, ⁶Seoul National University, Seoul, Republic of Korea

There is increasing evidence that myelin can be directly involved in Parkinson's disease (PD). We investigated the utility of ViSTa myelin water imaging (MWI) to characterize changes in myelination in PD. Slight decrease of global white matter myelin water fraction (MWF) was observed in PD patients. MWF was also associated with cognitive status, while no such association was found between DTI metrics and cognitive status. These indicated that MWF may potentially be a more specific biomarker for dysmyelination in the brain.

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