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Abstract #1513

Default mode network connectivity differences in levodopa responsive subtypes of Parkinson’s disease patients with freezing of gait.

Karthik R Sreenivasan1, Xiaowei Zhuang1, Jason Longhurst1, Zhengshi Yang1, Dietmar Cordes1, Aaron Ritter1, Jessica Caldwell1, Jeffrey L Cummings1, Zoltan Mari1, Irene Litvan2, Brent Bluett3, and Virendra Mishra1
1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2University of California San Diego, La Jolla, CA, United States, 3Stanford University, Palo Alto, CA, United States

Dopaminergic deficiency can cause altered deactivation of the default mode network (DMN) connectivity, which subsequently impacts executive task performance resulting in freezing of gait (FOG). While the majority of Parkinson’s disease (PD) patients with FOG (PD-FOG) are responsive to levodopa, about 36% of PD patients are levodopa-resistant. Our results show increased DMN connectivity in levodopa-resistant PD-FOG group. Furthermore, we found that altered network connectivity in the levodopa-resistant group was correlated differently with neuropsychological measures. To the best of our knowledge this is the first study to investigate the functional connectivity differences in levodopa-resistant subtypes in PD-FOG.

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