Freezing-of-gait (FoG) which is one of the main causes of falls in Parkinson’s disease (PD), results in significant morbidity and mortality. Currently, there are no robust methods of elucidating the neural mechanisms underlying this disabling aspect of PD. Utilizing a well-characterized cohort of PD-patients with-FoG (PD-FoG), PD-patients without-FoG (PD-nFoG), and healthy controls, we showed that diffusion kurtosis imaging and free-water corrected single-tensor diffusion MRI (dMRI)-derived measures identified significant differences in dMRI-derived measures between PD-FoG and PD-nFoG. Our study indicate that these beyond single-tensor dMRI models may identify robust and generalizable dMRI-derived measures to elucidate the neural mechanisms underlying PD-FoG.
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