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Abstract #1516

Investigating Iron deposition in the Substantia Nigra of Early Parkinson’s Disease and Idiopathic REM Sleep Behavior Disorder using QSM and R2*

Rahul Gaurav1,2, Romain Valabregue1, Nadya Pyatigorskaya1, Emma Biondetti1, Graziella Mangone3, Claire Ewenczyk4, Matthew Hutchison5, Isabelle Arnulf6, Jean-Christophe Corvol4, Marie Vidailhet4, Mathieu D. Santin1, and Stephane Lehericy1
1CENIR - Center for Neuroimaging Research, ICM - Brain and Spine Institute, Paris, France, 2Move'IT - Movement Investigations and Therapeutics, ICM - Brain and Spine Institute, Paris, France, 3Clinical Investigation Center (CIC-9503), INSERM - French National Institute of Medical Research and Health, Paris, France, 4Department of Neurology, Pitie-Salpetriere Hospital, Paris, France, 5Biogen Inc., Cambridge, MA, United States, 6Sleep Disorders Unit, Pitie-Salpetriere Hospital, Paris, France

Parkinson’s disease (PD) and idiopathic rapid eye movement sleep behavior disorder (iRBD) demonstrate neurodegenerative changes in the substantia nigra (SN) associated with an increase in iron deposition in PD patients. We aimed to quantify iron overload in the SN in early stage PD and iRBD patients using QSM-based and neuromelanin (NM)-based automated segmentation for QSM and R2* maps. We observed an increase in iron deposition in both early PD and iRBD patients with respect to healthy volunteers (HV).

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