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Abstract #1518

In-vivo Visualization of Locus Coeruleus using MTC-STAGE Imaging

Yu Liu1, Jun Chen Li1,2, Yongsheng Chen3, Naying He1, Zhijia Jin1, Weibo Chen4, Fuhua Yan1, and Ewart Mark Haacke1,5,6
1Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 2Radiology, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu, China, 3Neurology, Wayne State University, Detroit, MI, United States, 4Philips Healthcare, Shanghai, China, 5Radiology, Wayne State University, Detroit, MI, United States, 6Biomedical Engineering, Wayne State University, Detroit, MI, United States

The locus coeruleus (LC) is mainly responsible for the synthesis of noradrenaline in the brain. Pathological alterations of the LC are involved in many neurodegenerative diseases. In this work, we use the tissue properties (spin density and T1 value) of the LC extracted from an MTC-STAGE (strategically acquired gradient echo) susceptibility weighted imaging protocol. Choosing the right flip angle and resolution can provide optimal visualization of the LC. We found that a short echo scan, with a flip angle of 25-30o and a resolution of 0.67 x 0.67 x 1.34mm3 provides the best visualization of the LC.

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