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Abstract #1519

Investigating Functional Connectivity of Substantia Nigra pars compacta in Parkinson’s Disease

Apoorva Safai1, Shweta Prasad2,3, Jitender Saini4, Pramod Pal2, and Madhura Ingalhalikar5
1Symbiosis Center of Medical Image Analysis, Symbiosis International University, PUNE, India, 2Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India, 3Department of Clinical Neurosciences, National Institute of Mental Health and Neurosciences, Bangalore, India, 4Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, India, 5Symbiosis Center of Medical Image Analysis, Symbiosis International University, Pune, India

Parkinson’s disease (PD) is characterized by loss of dopaminergic neurons in Substantia Nigra pars compacta (SNc). SNc to whole brain resting state functional connectivity (rsFC) was compared between healthy controls (HC) and patients with PD to study the functional network of SNc in PD, and its association with disease progression was evaluated using a neuromelanin sensitive MRI based probabilistic atlas of SNc. Putamen, cerebellum and insular cortex connectivity with SNc was significantly reduced in PD as compared to HC. Widespread frontal, occipital regions, SMA and cerebellum were associated with duration and severity of PD.

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