Abstract #1519

Investigating Functional Connectivity of Substantia Nigra pars compacta in Parkinson’s Disease

Apoorva Safai¹, Shweta Prasad^2,3, Jitender Saini⁴, Pramod Pal², and Madhura Ingalhalikar⁵

¹Symbiosis Center of Medical Image Analysis, Symbiosis International University, PUNE, India, ²Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India, ³Department of Clinical Neurosciences, National Institute of Mental Health and Neurosciences, Bangalore, India, ⁴Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, India, ⁵Symbiosis Center of Medical Image Analysis, Symbiosis International University, Pune, India

Parkinson’s disease (PD) is characterized by loss of dopaminergic neurons in Substantia Nigra pars compacta (SNc). SNc to whole brain resting state functional connectivity (rsFC) was compared between healthy controls (HC) and patients with PD to study the functional network of SNc in PD, and its association with disease progression was evaluated using a neuromelanin sensitive MRI based probabilistic atlas of SNc. Putamen, cerebellum and insular cortex connectivity with SNc was significantly reduced in PD as compared to HC. Widespread frontal, occipital regions, SMA and cerebellum were associated with duration and severity of PD.

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