Abstract #1521

Quantifying Nigrosome-1 Loss in the Substantia Nigra on Susceptibility-Map Weighted Images in Essential Tremor and Parkinson’s Disease

Septian Hartono^1,2, Isabel Hui Min Chew³, Amanda Jieying Lee³, Joey Xin Yi Oh³, Leon Qi Rong Ooi⁴, Yao-Chia Shih³, Jongho Lee⁵, Zheyu Xu^1,2, Eng King Tan^1,2, and Ling Ling Chan^2,3

¹Department of Neurology, National Neuroscience Institute, Singapore, Singapore, ²Duke-NUS Medical School, Singapore, Singapore, ³Department of Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore, ⁴Department of Electrical & Computer Engineering, National University of Singapore, Singapore, Singapore, ⁵Department of Electrical & Computer Engineering, Seoul National University, Seoul, Korea, Republic of

Our study is the first to investigate the value of susceptibility map-weighted imaging in quantifying Nigrosome-1 loss in the substantia nigra to distinguish between tremor-dominant Parkinson’s disease (TDPD) and Essential Tremor (ET). Region-of-interest (ROI) masks of the Substantia Nigra and midbrain background were manually drawn on SMWI images of 50 subjects comprising 18 healthy controls, 25 ET and 7 TDPD patients. The SN in TDPD patients contained significantly more voxels more hypointense than the background than in ET patients. This could be explained by greater Nigrosome-1 loss and iron deposition in TDPD patients early in the disease.

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