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Abstract #1526

Investigation of subcortical brain structures in patients with Parkinson's disease using a quantitative susceptibility mapping atlas

Boliang Yu1, Ling Li2, Xueling Liu2, Naying He3, Hongjiang Wei4, Chuantao Zuo2, Fuhua Yan3, and Yuyao Zhang1
1School of Information Science and Technology, ShanghaiTech University, Shanghai, China, 2PET Center, Huashan Hospital, Fudan University, Shanghai, China, 3Department of Radiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, 4Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

A limited number of atlases have been constructed using quantitative susceptibility mapping (QSM) images from subjects with Parkinson’s disease (PD), and given disease-specific subcortical structures. In this work, we generated three standard-space templates i.e. the hybrid, QSM and T1w atlas, which kept good image quality to observe brain white, gray matter, and deep-brain nuclei. Based on the atlases, we achieved the manual annotation of a few brain subcortical structures, e.g. globus pallidus, substantia nigra, subthalamic nucleus and thalamus. The results gave the position and shape of subcortical nuclei which could be meaningful for the research and surgical treatment of PD.

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