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Abstract #1525

Free-water imaging in Substantia Nigra in Parkinson’s disease: A Neuromelanin Sensitive MRI Atlas Based Study

Apurva Shah1, Jacob Antony Alapatt2, Shweta Prasad3, Jitender Saini4, Pramod Pal3, Ragini Verma2, and Madhura Ingalhalikar1
1Symbiosis Center for Medical Image Analysis, Symbiosis International University, Pune, India, 2Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 3Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, India, 4Department of Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, India

Parkinson’s disease is characterized by degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). To study the micro-structural and free-water (FW) changes using diffusion-MRI in the SNc it is critical to extract SNc accurately. Our work employs a neuromelanin sensitive MRI based atlas to delineate the SNc and demonstrates significant FW and FW eliminated microstructural alterations in a large cohort of PD (with and without psychosis) and its association with PD severity, indicative of novel diagnostic and progression markers of PD which however demonstrate no role in genesis of psychosis in PD.

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