Abstract #1525

Free-water imaging in Substantia Nigra in Parkinson’s disease: A Neuromelanin Sensitive MRI Atlas Based Study

Apurva Shah¹, Jacob Antony Alapatt², Shweta Prasad³, Jitender Saini⁴, Pramod Pal³, Ragini Verma², and Madhura Ingalhalikar¹

¹Symbiosis Center for Medical Image Analysis, Symbiosis International University, Pune, India, ²Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, India, ⁴Department of Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, India

Parkinson’s disease is characterized by degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). To study the micro-structural and free-water (FW) changes using diffusion-MRI in the SNc it is critical to extract SNc accurately. Our work employs a neuromelanin sensitive MRI based atlas to delineate the SNc and demonstrates significant FW and FW eliminated microstructural alterations in a large cohort of PD (with and without psychosis) and its association with PD severity, indicative of novel diagnostic and progression markers of PD which however demonstrate no role in genesis of psychosis in PD.

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