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Abstract #1528

Can short echo time magnitude image of quantitative susceptibility mapping resembles neuromelanin-sensitive MRI image of the substantia nigra?

Xueling Liu1, Liqin Yang1, Yuxin Li1, Daoying Geng1, Pu-Yeh Wu2, and Yong Zhang2
1Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China, 2GE Healthcare China, Beijing, Shanghai, China

Loss of melanized dopaminergic neurons(1) and iron deposition(2) in substantia nigra (SN) were pathological hallmarks of Parkinson’s disease (PD). Susceptibility images from QSM could detect iron deposition(3, 4) while neuromelanin-sensitive MRI (NM-MRI) could reflect change of melanized dopaminergic neurons(5, 6) in SN. In this study, we found highly spatial similarity of SNhyperintense on Mag1 images from QSM and on NM-MRI images. PD-patients could be differentiated from old HCs on Mag1 images as similar as that on NM-MRI images. Combined with Mag1 and susceptibility images, QSM could provide a promising imaging biomarker for iron deposition and NM deficiency in PD simultaneously.

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