Loss of melanized dopaminergic neurons(1) and iron deposition(2) in substantia nigra (SN) were pathological hallmarks of Parkinson’s disease (PD). Susceptibility images from QSM could detect iron deposition(3, 4) while neuromelanin-sensitive MRI (NM-MRI) could reflect change of melanized dopaminergic neurons(5, 6) in SN. In this study, we found highly spatial similarity of SNhyperintense on Mag1 images from QSM and on NM-MRI images. PD-patients could be differentiated from old HCs on Mag1 images as similar as that on NM-MRI images. Combined with Mag1 and susceptibility images, QSM could provide a promising imaging biomarker for iron deposition and NM deficiency in PD simultaneously.
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