Abstract #1529

Assessing the Diagnostic Power of Parkinson’s Disease Biomarkers: Nigrosome-1 Sign, Neuromelanin and Iron Quantification

Zhijia Jin¹, Zenghui Cheng¹, Naying He¹, Pei Huang², Sean K. Sethi^3,4, Mojtaba Jokar³, Weibo Chen⁵, Shengdi Chen², Fuhua Yan¹, and E. Mark Haacke^1,3,4,6

¹Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ³Magnetic Resonance Innovations, Inc., Bingham Farms, MI, United States, ⁴Department of Radiology, Wayne State University, Detroit, MI, United States, ⁵Philips Healthcare, Shanghai, China, ⁶Department of Biomedical Engineering, Wayne State University, Detroit, MI, United States

Twenty-nine Parkinson’s disease (PD) patients and 29 age- and sex-matched healthy controls (HCs) were scanned using a single 3D gradient echo magnetization transfer sequence to evaluate neuromelanin volume, global and regional iron content, and the appearance of nigrosome-1 territory (the “N1 sign”) in the substantia nigra. Iron increase and neuromelanin volume reduction were found in PD patients compared to HCs. 21/29 and 4/29 of PD patients showed bilateral and unilateral loss of the N1 sign, respectively. Combining the N1 sign with neuromelanin volume, global iron content and regional iron content respectively improved diagnostic performance to differentiate PD patients from HCs.

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