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Abstract #1529

Assessing the Diagnostic Power of Parkinson’s Disease Biomarkers: Nigrosome-1 Sign, Neuromelanin and Iron Quantification

Zhijia Jin1, Zenghui Cheng1, Naying He1, Pei Huang2, Sean K. Sethi3,4, Mojtaba Jokar3, Weibo Chen5, Shengdi Chen2, Fuhua Yan1, and E. Mark Haacke1,3,4,6
1Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 2Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 3Magnetic Resonance Innovations, Inc., Bingham Farms, MI, United States, 4Department of Radiology, Wayne State University, Detroit, MI, United States, 5Philips Healthcare, Shanghai, China, 6Department of Biomedical Engineering, Wayne State University, Detroit, MI, United States

Twenty-nine Parkinson’s disease (PD) patients and 29 age- and sex-matched healthy controls (HCs) were scanned using a single 3D gradient echo magnetization transfer sequence to evaluate neuromelanin volume, global and regional iron content, and the appearance of nigrosome-1 territory (the “N1 sign”) in the substantia nigra. Iron increase and neuromelanin volume reduction were found in PD patients compared to HCs. 21/29 and 4/29 of PD patients showed bilateral and unilateral loss of the N1 sign, respectively. Combining the N1 sign with neuromelanin volume, global iron content and regional iron content respectively improved diagnostic performance to differentiate PD patients from HCs.

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