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Abstract #1535

White Matter Plasticity in Newly Diagnosed Parkinson’s Disease With/Without Mild Cognitive Impairment

Christina Andica1, Koji Kamagata1, Yuya Saito1,2, Wataru Uchida1,2, Akifumi Hagiwara1, Shohei Fujita1,3, Syo Murata1, Masaaki Hori1,4, and Shigeki Aoki1
1Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, 3Department of Radiology, Graduate School of Medicine, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan, 4Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan

We evaluated the white matter (WM) of patients with newly diagnosed Parkinson’s disease (PD) with normal cognition (PD-NC) and mild cognitive impairment (PD-MCI) using diffusion tensor imaging (DTI) and free-water elimination DTI. Increased fractional anisotropy and decreased mean diffusivity and radial diffusivity in patients with PD suggested compensatory neural circuit reorganization. Changes were less extensive in WM areas previously considered vulnerable to MCI in the PD-MCI group than in the PD-NC group. Longitudinal analyses indicated neural compensation in the PD-NC group after 1 year. Overall, extensive and long compensatory mechanisms may be associated with preserved cognitive function in PD.

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