Abstract #1535

White Matter Plasticity in Newly Diagnosed Parkinson’s Disease With/Without Mild Cognitive Impairment

Christina Andica¹, Koji Kamagata¹, Yuya Saito^1,2, Wataru Uchida^1,2, Akifumi Hagiwara¹, Shohei Fujita^1,3, Syo Murata¹, Masaaki Hori^1,4, and Shigeki Aoki¹

¹Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan, ²Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, ³Department of Radiology, Graduate School of Medicine, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan, ⁴Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan

We evaluated the white matter (WM) of patients with newly diagnosed Parkinson’s disease (PD) with normal cognition (PD-NC) and mild cognitive impairment (PD-MCI) using diffusion tensor imaging (DTI) and free-water elimination DTI. Increased fractional anisotropy and decreased mean diffusivity and radial diffusivity in patients with PD suggested compensatory neural circuit reorganization. Changes were less extensive in WM areas previously considered vulnerable to MCI in the PD-MCI group than in the PD-NC group. Longitudinal analyses indicated neural compensation in the PD-NC group after 1 year. Overall, extensive and long compensatory mechanisms may be associated with preserved cognitive function in PD.

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