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Abstract #1551

Increases in Arteriolar Cerebral Blood Volume in Huntington’s Disease Measured with Inflow-based Vascular-space-occupancy (iVASO) MRI at 7T

Chunming Gu1,2,3, Martin Kronenbuerger4,5, Di Cao1,2,3, Adrian G. Paez1,2, Xinyuan Miao1,2, Xirui Hou1,3, Jee Bang5,6, Kia E. Ultz5, Wenzhen Duan6,7, Russell L. Margolis5,6, Peter C. M. van Zijl1,2, Christopher A. Ross5,6,7,8, and Jun Hua1,2
1The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, 4Department of Neurology, University of Greifswald, Greifswald, Germany, 5Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 6Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 7The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 8Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Significantly elevated arteriolar cerebral blood volume (CBVa) in premanifest Huntington’s Disease (HD) patients has been reported previously. In this study, inflow-based vascular-space-occupancy (iVASO) MRI at 7 Tesla was used to measure CBVa in HD patients longitudinally. We found significant longitudinal increases in CBVa in premanifest HD patients in several brain regions primarily related to motor, visual and cognitive functions, which suggests CBVa as a potential candidate biomarker for HD especially in the premanifest stage.

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