Abstract #1550

Revealing reduced CBF and prolonged ATT in prodromal AD using a 3D pCASL with Hadamard encoded multiple PLDs

Yang Wang¹, Alexander Cohen¹, Guanyu Chen², Veena Nair³, Piero Antuono⁴, Malgorzata Franczak⁴, Vivek Prabhakaran³, Barbara Bendlin⁵, Shi-Jiang Li², and the Alzheimer’s Disease Connectome Project⁶

¹Radiology, Medical College of Wisconsin, Milwaukee, WI, United States, ²Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States, ³Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, ⁴Neurology, Medical College of Wisconsin, Milwaukee, WI, United States, ⁵Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, ⁶Medical College of Wisconsin, Milwaukee, WI, United States

Measured using an advanced 3D pCASL with Hadamard encoded multiple PLDs, patients with MCI showed different patterns of reduced CBF and prolonged ATT in comparison with both AD patients and healthy controls, where CBF and ATT changes highly correlated with severity of disease as assessed by neuropsychological test scores. These findings raised the speculation of underlying vascular abnormality in prodromal AD. Our results also suggested that ATT could serve as useful hemodynamic measure of itself, may be of diagnostic utility for prodromal AD or vascular dementia.

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