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Abstract #1549

Brain Iron Deposition and Cognitive Impairment in Idiopathic RBD: A Quantitative Susceptibility Mapping Study

Chao Chai1, Huiying Wang1, Tong Zhang2, Jinxia Zhu3, Xianchang Zhang3, E Mark Haacke4, Shuang Xia1, and Wen Shen1
1Department of Radiology, Tianjin First Central Hospital, Tianjin Medical Imaging Institute, Tianjin, China, 2School of Graduates, Tianjin Medical Univeristy, Tianjin, China, 3MR Collaboration, Siemens Healthcare Ltd., Beijing, China, 4Department of Radiology, Wayne State University, Detroit, MI, United States

Iron metabolism is a research focus in α‑synucleinopathies. Excessive iron deposition may damage neurons and induce cognitive impairment. However, research on brain iron deposition in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) is lacking. Using quantitative susceptibility mapping (QSM), the present study showed that iRBD patients have greater brain iron deposition in the substantia nigra and dentate nucleus than healthy controls (HCs). Additionally, brain iron deposition in the striatum and cerebellum was associated with cognitive impairment, suggesting the potential of QSM as an auxiliary biomarker for neurodegeneration and the early evaluation of cognitive decline in iRBD patients.

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