Abstract #1557

Neuro-inflammation is associated with WMH burden at baseline and predicts longitudinal cognitive decline in cerebral small vessel disease

Chunwei Ying¹, Andria L. Ford², Michael M. Binkley², Yasheng Chen², Peter Kang², Jon Christensen¹, Qing Wang¹, Lisa Cash¹, Jason Hassenstab², Jin-Moo Lee^1,2, Tammie L. S. Benzinger^1,3, and Hongyu An¹

¹Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United States, ²Department of Neurology, Washington University School of Medicine, St. Louis, MO, United States, ³Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, United States

Neuro-inflammation has been suggested as an important pathogenesis factor for cerebral small vessel disease, but direct evidence in human is lacking. In this study, we found that neuro-inflammation, measured by ¹¹C-PK11195 uptake, was associated with white matter hyperintensities burden at baseline. More importantly, it predicted cognitive decline in a longitudinal follow-up study.

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