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Abstract #1558

Increased Cerebral Blood flow was Correlated with Neurocognitive Dysfunction in Chronic Hemodialysis Patients: A  Arterial Spin Labeling Study

Chao Chai1, Huiying Wang1, Tong Zhang2, Jinping Li3, Yingying Han3, Jinxia Zhu4, Xianchang Zhang4, Shuang Xia1, and Wen Shen1
1Department of Radiology, Tianjin First Central Hospital, Tianjin Medical Imaging Institute, Tianjin, China, 2School of Graduates, Tianjin Medical Univeristy, Tianjin, China, 3Department of Hemodialysis, Tianjin First Central Hospital, Tianjin, China, 4MR Collaboration, Siemens Healthcare Ltd., Beijing, China

Cerebral blood flow (CBF) can be significantly reduced during a single hemodialysis session. However, few studies have investigated the effect of long-term hemodialysis on CBF and its correlation with neuropsychological tests. This study used pulsed arterial spin labeling to show that hemodialysis patients had significantly increased CBF in some cerebral regions. Increased CBF of the right opercular and triangular part of inferior frontal gyrus was negatively correlated with Mini Mental State Examination (MMSE) scores, and after adjusting for hemoglobin and hematocrit levels, these correlations became stronger. Dialysis duration, hemoglobin, hematocrit, and serum phosphorus were clinical risk factors for increased CBF.

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