Abstract #1559

Higher levels of myelination were observed in chronic fatigue syndrome patients relative to healthy controls

KIRAN THAPALIYA^1,2, Sonya Marshall-Gradisnik¹, Don Staines¹, Sandeep Bhuta³, Timothy Ireland³, and Leighton Barnden¹

¹Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia, ²Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, ³Gold Coast University Hospital, Gold coast, Australia

Myalgic Encephalomyelitis (ME)/Chronic fatigue syndrome (CFS) patients suffer from a variety of physical and neurological complaints indicating the central nervous system plays a role in CFS pathophysiology. Studies based on genetic, immune system, psychiatric, and brain volume abnormalities and white matter hyperintensities have been investigated to identify the pathomechanism of this disease. However, assessment of myelination in brain regions between ME/CFS patients and healthy controls has not been investigated. In this study, we showed elevated myelination in white matter regions and grey matter regions in ME/CFS patients relative to normal controls.

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