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Abstract #1560

Delayed cerebrovascular response within deep white matter may alter the cortical-subcortical connections in small vessel disease patients

Yi-Tien Li1,2, Yi-Wen Chen1, and David Yen-Ting Chen1,3
1Department of Radiology, Taipei Medical University - Shuang Ho Hospital, New Taipei, Taiwan, 2Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, 3Department of Radiology, Stanford University, Palo Alto, CA, United States

We applied cross-correlation method on breath-holding task to estimate the cerebrovascular response (CVR) strength and latency within deep white matter. The CVR latency showed significant negative correlation with working memory (WM) 1-back accuracy (r = -0.546, p = 0.009). Further, the significant negative correlation between the average CVR latency within deep white matter and the functional connectivity in specific regions of WM activation area, including left anterior insular cortex and bilateral putamen was found. The result suggested that the changes of cortical-subcortical connections in cerebral small vessel disease can be reflected by the delayed CVR latency within deep white matter.

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