We applied cross-correlation method on breath-holding task to estimate the cerebrovascular response (CVR) strength and latency within deep white matter. The CVR latency showed significant negative correlation with working memory (WM) 1-back accuracy (r = -0.546, p = 0.009). Further, the significant negative correlation between the average CVR latency within deep white matter and the functional connectivity in specific regions of WM activation area, including left anterior insular cortex and bilateral putamen was found. The result suggested that the changes of cortical-subcortical connections in cerebral small vessel disease can be reflected by the delayed CVR latency within deep white matter.
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