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Abstract #1562

Detecting brain structural abnormality associated with breast cancer and chemotherapy using GQI

Wei Chuang1, Vincent Chin-Hung Chen2,3, Yuan-Hsiung Tsai4, and Jun-Cheng Weng1,3,5
1Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan, 2School of Medicine, Chang Gung University, Taoyuan, Taiwan, 3Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, 4Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi, Taiwan, 5Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan

Breast neoplasms are the most common cancer among women. Whether received adjuvant chemotherapy or not, lots of them presented cognitive impairment which decreased their quality of life. Therefore, we attempted to use generalized q-sampling imaging (GQI) to detect the white matter alteration between groups that may due to post-traumatic stress disorder (PTSD), post-traumatic growth (PTG) and chemotherapy. Our results showed the differences in the brain regions associated with cognition, emotion, and execution, such as angular gyrus, cingulate gyrus and so on. It indicted traumatic stressor or chemotoxicity can cause myelin injuries in these regions.

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