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Abstract #1563

Comparison of brain atrophy in patients with type 2 diabetes from the Diabetes and Dementia (D2) study and stroke patients from the CANVAS study

Mohamed Salah Khlif1, Carolina Restrepo1, Emilio Werden1, Laura Bird1, Sheila K. Patel1,2, Rebecca Singleton1, Jeffrey D. Zajac2,3, Richard MacIsaac4, Elif I. Ekinci2,3, Louise M. Burrell2,5, and Amy Brodtmann1,2,6
1The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia, 2Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Australia, 3Austin Health Endocrine Centre, Heidelberg, Australia, 4Department of Endocrinology & Diabetes, St Vincent's Hospital, Melbourne, Australia, 5Department of Cardiology, Austin Health, Heidelberg, Australia, 6Department of Neurology, Austin Health, Heidelberg, Australia

Type 2 diabetes and stroke are associated with reduced brain volumes and independently present a high risk for cognitive impairment or dementia. The interaction between diabetes and stroke and its effects on brain atrophy are unknown. We used linear mixed-effect modelling to estimate rates of atrophy over two years based on FreeSurfer segmentation of MR images of healthy participants and patients with type 2 diabetes and/or stroke. Cerebral atrophy, defined by volume reductions in specific regions of interest, was accelerated the most in the group with only type 2 diabetes. Thalamus was affected more by stroke.

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