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Abstract #1564

Proximal Nerve Quantitative MRI in Charcot-Marie-Tooth (CMT) Diseases

Yongsheng Chen1, E. Mark Haacke2, Yang Xuan2, Melody Hackett1, Sadaf Saba3, Bo Hu1, Daniel Moiseev1, and Jun Li1,3,4,5
1Department of Neurology, Wayne State University, Detroit, MI, United States, 2Department of Radiology, Wayne State University, Detroit, MI, United States, 3Center for Molecular Medicine & Genetics, Wayne State University, Detroit, MI, United States, 4Department of Biochemistry, Microbiology and Immunology, Wayne State University, Detroit, MI, United States, 5John D. Dingell VA Medical Center, Detroit, MI, United States

To test the hypothesis that quantitative MRI (qMRI) detects proximal nerve dysmyelination and axonal degeneration in Charcot-Marie-Tooth (CMT) diseases. Nine qMRI indices were collected, including whole muscle mean fat fraction (wmmFF), nerve fascicular cross-sectional area (fCSA), magnetization transfer ratio (MTR), T1, proton density (PD), R2, R2*, mean diffusivity (MD) and fractional anisotropy (FA). Compared to controls, patients with CMT had significantly elevated fCSA, T1, PD, T2* and MD for both divisions of sciatic nerves and wmmFF, elevated T2 for the tibial division but not the peroneal division, and decreased MTR for both divisions of sciatic nerves.

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