Abstract #1564

Proximal Nerve Quantitative MRI in Charcot-Marie-Tooth (CMT) Diseases

Yongsheng Chen¹, E. Mark Haacke², Yang Xuan², Melody Hackett¹, Sadaf Saba³, Bo Hu¹, Daniel Moiseev¹, and Jun Li^1,3,4,5

¹Department of Neurology, Wayne State University, Detroit, MI, United States, ²Department of Radiology, Wayne State University, Detroit, MI, United States, ³Center for Molecular Medicine & Genetics, Wayne State University, Detroit, MI, United States, ⁴Department of Biochemistry, Microbiology and Immunology, Wayne State University, Detroit, MI, United States, ⁵John D. Dingell VA Medical Center, Detroit, MI, United States

To test the hypothesis that quantitative MRI (qMRI) detects proximal nerve dysmyelination and axonal degeneration in Charcot-Marie-Tooth (CMT) diseases. Nine qMRI indices were collected, including whole muscle mean fat fraction (wmmFF), nerve fascicular cross-sectional area (fCSA), magnetization transfer ratio (MTR), T1, proton density (PD), R2, R2*, mean diffusivity (MD) and fractional anisotropy (FA). Compared to controls, patients with CMT had significantly elevated fCSA, T1, PD, T2* and MD for both divisions of sciatic nerves and wmmFF, elevated T2 for the tibial division but not the peroneal division, and decreased MTR for both divisions of sciatic nerves.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.