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Abstract #1565

STRUCTURAL PLASTICITY IN THE BRAIN OF CMT1A PATIENTS? A COMBINED VBM AND TBSS STUDY

Sirio Cocozza1, Giuseppe Pontillo1, Raffaele Dubbioso1, Stefano Tozza1, Daniele Severi1, Lucio Santoro1, Andrea Elefante1, Fiore Manganelli1, Arturo Brunetti1, and Mario Quarantelli2
1University "Federico II", Naples, Italy, 2National Research Council, Naples, Italy

We investigated the presence of gray matter (GM) and white matter (GM) structural modifications in a homogeneous group of genetically defined CMT1A patients, by means of VBM and TBSS analyses, respectively. We found increased GM volume in CMT1A patients compared to HC encompassing the right paravermian portions of the cerebellar lobules III, IV and V, showing an inverse correlation with electrophysiological measures. These structural changes may reflect compensatory mechanisms in response to CMT1A peripheral nerve pathology, providing new insights into the comprehension of CNS physiopathology and its role in the development of clinical disability in this condition.

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