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Abstract #1569

Serial assessment of magnetic susceptibility in the primary motor cortex in limb-onset Amyotrophic Lateral Sclerosis

Anjan Bhattarai1,2, Zhaolin Chen2, Phillip G. D. Ward2, Paul Talman3, Susan Mathers4, Thanh Phan5, Caron Chapman4, James Howe4, Sarah Lee4, Yennie Lie4, Gary F Egan2, and Phyllis Chua1,4
1Department of Psychiatry, Monash University, Clayton, Australia, 2Monash Biomedical Imaging, Monash University, Clayton, Australia, 3Department of Neuroscience, Barwon Health, Geelong, Australia, 4Statewide Progressive Neurological Services, Calvary Health Care Bethlehem, South Caulfield, Australia, 5Department of Neuroscience, Monash Health, Clayton, Australia

We performed in-vivo measurements of the magnetic susceptibility in the motor cortex in individuals with Amyotrophic Lateral Sclerosis (ALS) at baseline and six-month follow-up, and healthy controls at baseline using Quantitative Susceptibility Mapping (QSM). The results show significant susceptibility difference between individuals with ALS compared to healthy controls. There was a trend towards more pronounced susceptibility changes in lumbar onset compared to healthy controls than cervical onset ALS compared to healthy controls. These findings may lead to the development of a sensitive neuroimaging biomarker that can provide meaningful insights into pathophysiologic changes in ALS subtypes.

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