Meeting Banner
Abstract #1570

Disrupted grey matter network morphology in amyotrophic lateral sclerosis

Jing Yang1, Du Lei1,2, Xueling Suo1, and Qiyong Gong1,3
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2University of Cincinnati, Cincinnati, OH, United States, 3Psychoradiology Research Unit of Chinese Academy of Medical Sciences (2018RU011), Chengdu, China

The present psychoradiological study demonstrated significant alterations both in global and nodal topological properties of single-subject brain morphological networks in a relatively large population of patients with ALS relative to HCs. This was achieved by combining graph theoretical analysis with a method of describing patterns of intercortical morphological similarities in individual participants using structural MRI data. We found that ALS showed a weaker small world organized brain network in global properties and decreased nodal centralities mainly in prefrontal-limbic network relative to HCs. Further, the nodal efficiency of right inferior frontal gyrus was positively correlated to ALSFRS in ALS group.

This abstract and the presentation materials are available to members only; a login is required.

Join Here