The present psychoradiological study demonstrated
significant alterations both in global and nodal topological properties of
single-subject brain morphological networks in a relatively large population of
patients with ALS relative to HCs. This was achieved by combining graph
theoretical analysis with a method of describing patterns of intercortical morphological
similarities in individual participants using structural MRI data. We found
that ALS showed a weaker small world organized brain network in global
properties and decreased nodal centralities mainly in prefrontal-limbic network
relative to HCs. Further, the nodal efficiency of right inferior frontal
gyrus was positively correlated to ALSFRS
in ALS group.
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