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Abstract #1571

Spatial Distribution Patterns of Secondary White Matter Tract Degeneration in Amyotrophic Lateral Sclerosis  

Hagen H Kitzler1, Paul Kuntke1, Carolin Schwamborn1, Hannes Wahl1, Rene Guenther2, Andreas Herrmann3, Sean C Deoni4, and Jennifer Linn1
1Neuroradiology, Technische Universität Dresden, Dresden, Germany, 2Neurology, Technische Universität Dresden, Dresden, Germany, 3Neurology, Universitätsmedizin Rostock, Rostock, Germany, 4Alpert Medical School, Brown University, Providence, RI, United States

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease of primary cortical neuronal pathology and central nervous system multisystem involvement including related white matter. Based on previous findings of early myelination changes we aimed to investigate the spatial distribution of changes of markers of axonal (diffusion) and myelin (relaxation) integrity of the related motor corticospinal tract (CST). We found different pattern with minor, predominantly diffusion or predominantly relaxation, and extensive ubiquitary alteration. However, heterogeneous distribution of changes suggest a non-uniform secondary CST degeneration and limited prognostic value of ALS disease course.

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