Abstract #1573

Method for quantitative evaluation of the substantia nigra using phase-sensitive inversion recovery in 1.5-T magnetic resonance imaging

Tomohisa Doi¹, Yasuhiro Fujiwara², and Hirotoshi Maruyama³

¹Graduate School of Health Sciences, Kumamoto University, Kumamoto, Japan, ²Department of Medical Image Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan, ³Department of Radiology, National Hospital Organization Kumamoto Saisyun Medical Center, Kumamoto, Japan

Degeneration of the substantia nigra cannot be evaluated using neuromelanin imaging at 1.5 T. Therefore, an imaging method to quantitatively evaluate the substantia nigra with 1.5-T magnetic resonance imaging is required. This study aimed to investigate whether the substantia nigra can be quantitatively evaluated by acquiring a T₁ map using three-dimensional phase-sensitive inversion recovery (PSIR) at 1.5 T. T₁ mapping using the PSIR sequence enables quantitative evaluation of the substantia nigra independent of the imaging parameters.

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