QSM has the potential of describing objectively iron accumulation in brain regions such as basal ganglia which is relevant in neurodegeneration with brain iron accumulation (NBIA). Herein, for accurately assessing iron accumulation, a new metric, high susceptibility density, is introduced against mean value pitfalls which may be hindered by negative susceptibility within ROIs. When analyzing iron accumulation in basal ganglia of 16 patients with subtypes PKAN dispersion, KUFOR lower and PLAN higher accumulation, MPAN separation was obeserved in the Globus Pallidus-Red Nucleus space compared to healthy volunteers.
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