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Abstract #1574

QSM Attributes of Neurodegeneration with Brain Iron Accumulation Disorders Subtypes in Basal Ganglia

Alpay Ozcan1, Ozge Uygun2, Fuat Kaan Aras1, Murat Gultekin3, Zuhal Yapici2, and Alp Dincer4
1Acibadem Mehmet Ali Aydinlar Univ., Istanbul, Turkey, 2Neurology, Istanbul University, Istanbul, Turkey, 3Neurology, Erciyes University, Kayseri, Turkey, 4Radiology, Acibadem Mehmet Ali Aydinlar Univ., Istanbul, Turkey

QSM has the potential of describing objectively iron accumulation in brain regions such as basal ganglia which is relevant in neurodegeneration with brain iron accumulation (NBIA). Herein, for accurately assessing iron accumulation, a new metric, high susceptibility density, is introduced against mean value pitfalls which may be hindered by negative susceptibility within ROIs. When analyzing iron accumulation in basal ganglia of 16 patients with subtypes PKAN dispersion, KUFOR lower and PLAN higher accumulation, MPAN separation was obeserved in the Globus Pallidus-Red Nucleus space compared to healthy volunteers.

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