Abstract #1575

The white matter impairment of Gordon-Holmes syndromes: a tracking based analysis

Lei Wei¹, KeLiang Chen², and He Wang^1,3

¹Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, shanghai, China, ²Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China, ShangHai, China, ³Human Phenome Institute, Fudan University, Shanghai, China, Shanghai, China

The Gordon-Holmes syndrome is an rare condiion caused by mutation of genes, few study has reported the finding of GHS by neuroimaging, but several studies has found the white matter abnormal in GHS brain. According the tracking based analysis. The different quantitative diffusion parameters suggest the white matter abnormal from different aspects. We firstly iinvestigated the white matter abnormal of GHS in the distribution of each diffusion property.

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