Abstract #1576

Gray Matter Changes of Pain-matrix Network in Patients with Acute Carbon Monoxide Intoxication

Ming-Chung Chou¹, Jei-Yuan Li², and Ping-Hong Lai³

¹Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan, ²Department of Neurology, E-Da Hospital, Kaohsiung, Taiwan, ³Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

This study performed a voxel-based morphometry to investigate global gray matter changes in patients with acute CO intoxication. The results show significantly decreased gray matter volumes mostly in the pain-matrix regions, and significantly increased gray matter volumes in the periaqueductal gray (pain-modulating center). In the pain-matrix regions, the GM volumes were significantly negatively correlated with duration of coma, suggesting that longer duration of coma may lead to more headache symptoms in patients with acute CO intoxication.

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