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Abstract #1577

Ex-vivo Imaging of Intracerebral Fetal Neural Transplants in a Huntington Patient at 7T: Graft Survival and Interconnectivity  11 year post-OP

David Lohr1, Philipp Capetian2, Bernhard Landwehrmeyer3, and Laura Maria Schreiber1
1Chair of Cellular and Molecular Imaging, Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg, Würzburg, Germany, 2Department of Neurology, University Hospital Würzburg, Würzburg, Germany, 3Department of Neurology, University Hospital Ulm, Ulm, Germany

The brain of a Huntington Disease (HD) patient who received neural fetal tissue transplants 11 years before her death, was analyzed ex-vivo in a 7T MRI scanner with a total scan time of 25 hours and 8 minutes. Signs of engrafted tissue could be found on all sites which received a stereotactic implantation (caudate nucleus, putamen) with a tendency to overgrowth for the right hemisphere. Deterministic fiber tracking based on DTI images clearly demonstrated interconnectivity of individual grafts to numerous brain regions.

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