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Abstract #1579

Lesion distribution and substrate in Type 1 Myotonic Dystrophy: comparison with Multiple Sclerosis

Sara Leddy1, Laura Serra2, Davide Esposito3, Camilla Vizzotto4, Gabriella Silvestri5, Antonio Petrucci6, Giovanni Meola7, Mara Cercignani2,8, and Marco Bozzali2,8
1Brighton and Sussex University Hospitals Trust, Brighton, United Kingdom, 2Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy, 3Department of Vascular and Endovascular Surgery, University of Florence, Florence, Italy, 4University of, Rome, Italy, 5Department of Geriatrics, Orthopedics and Neuroscience, Catholic University of Sacred Heart Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, 6UOC Neurologia e Neurofisiopatologia, AO San Camillo Forlanini, Rome, Italy, 7Department of Neurorehabilitation Sciences, Casa di Cura Policlinico, Milan, Italy, 8Department of Neuroscience, University of Sussex, Brighton, United Kingdom

This study compares the lesion distribution and substrate (by means of quantitative MRI) between patients with type 1 Myotonic Dystrophy (DM1) and patients with Multiple Sclerosis (MS). The main differences in anatomical distribution are the prevalence of anterior temporal lobe lesions in the former group, in the absence of cerebellum and brainstem lesions. MRI markers of myelination were not different between the normal appearing white matter of DM1 and healthy controls. By contrast they were reduced in lesions, but larger than in MS lesions.

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