Epilepsy is a common neurological disorder spread worldwide. Simple febrile seizures (simple FS) is convulsive disorder associated with fever. However, little known about diffusion changes during the developing brain. The study aimed was to assess the diffusion changes in epilepsy and simple FS at aged of 6 to 60 months, using diffusion tensor imaging (DTI). Through inter-group comparisons, fraction anisotropy (FA) decreased, and radial diffusivity (RD) increased in epileptic children compared to simple FS and control. These results suggested DTI is sensitive method in diagnosis delayed myelination in epilepsy, while simple FS have good prognosis due to different pathophysiological mechanism.