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Abstract #1581

White matter degeneration in Papez circuit is associated with memory function in patients with mesial temporal lobe epilepsy

HSI-YUAN HU1, Yao-Chia Shih2, Chang-Le Chen1, Horng-Huei Liou3, Yu-Ling Chang4, Yung-Chin Hsu5, and Wen-Yih Isaac Tseng6
1Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, Taipei, Taiwan, 2Department of Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore, Singapore, Singapore, 3Department of Neurology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan, Taipei, Taiwan, 4Department of Psychology, College of Science, National Taiwan University, Taipei, Taiwan, Taipei, Taiwan, 5AcroViz Technology, Inc., Taipei, Taiwan, Taipei, Taiwan, 6Molecular Imaging Center, National Taiwan University, Taipei, Taiwan, Taipei, Taiwan

Previous studies did not characterize side-specific associations between structural integrity of the Papez circuit and memory function in patients with mesial temporal lobe epilepsy (MTLE). Here, we used diffusion spectrum imaging (DSI) and T1-weighted MRI to calculate the white matter integrity and gray matter volume, respectively. The structural metrics were correlated with visual and verbal memory function scores assessed by neuropsychological test. The results showed distinct brain-behavior associations in two subtypes of MTLE.

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Abstract