Abstract #1581

White matter degeneration in Papez circuit is associated with memory function in patients with mesial temporal lobe epilepsy

HSI-YUAN HU¹, Yao-Chia Shih², Chang-Le Chen¹, Horng-Huei Liou³, Yu-Ling Chang⁴, Yung-Chin Hsu⁵, and Wen-Yih Isaac Tseng⁶

¹Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, Taipei, Taiwan, ²Department of Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore, Singapore, Singapore, ³Department of Neurology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan, Taipei, Taiwan, ⁴Department of Psychology, College of Science, National Taiwan University, Taipei, Taiwan, Taipei, Taiwan, ⁵AcroViz Technology, Inc., Taipei, Taiwan, Taipei, Taiwan, ⁶Molecular Imaging Center, National Taiwan University, Taipei, Taiwan, Taipei, Taiwan

Previous studies did not characterize side-specific associations between structural integrity of the Papez circuit and memory function in patients with mesial temporal lobe epilepsy (MTLE). Here, we used diffusion spectrum imaging (DSI) and T1-weighted MRI to calculate the white matter integrity and gray matter volume, respectively. The structural metrics were correlated with visual and verbal memory function scores assessed by neuropsychological test. The results showed distinct brain-behavior associations in two subtypes of MTLE.

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