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Abstract #1588

Changes in resting state connectivity and brain metabolites during a season of collegiate basketball: A pilot study

Candace C Fleischer1,2, Jeremy L Smith1, Maame Owusu-Ansah1, Selin Ekici1, Dongsuk Sung2, Ojaswa Prasad3, Brandon Mines4, and Jason W Allen1
1Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, 2Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States, 3Department of Medicine, Philadelphia College of Osteopathic Medicine, Suwanee, GA, United States, 4Department of Sports Medicine, Emory University School of Medicine, Atlanta, GA, United States

Sports-related traumatic brain injuries are difficult to diagnose and prognose due to a lack of standardized metrics. Furthermore, there has been limited research on the effects of repeated sub-concussive and sub-clinical injuries over time. In this study, we characterized changes in resting state connectivity and brain metabolites over a season of collegiate basketball in athletes without a diagnosed concussion. We observed significant changes in resting state connectivity and brain metabolites as a function of game time played. No changes in plasma inflammatory markers were observed over time, suggesting that brain changes were not driven by systemic inflammation.

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